Ccleaner is a freeware tool that cleans the HD and cleans the registry
http://www.ccleaner.com/
The best tuneup is manual
Uninstall any unneeded programs using Revo Uninstaller
http://www.download.com/Revo-Uninstaller/3000-2096_4-10687648.html?cdlPid=10892747
Or you can use Add/Remove programs in the control panel
Disable any unneeded startup programs
Go to start>run>msconfig>startup
Use this guide
http://www.bleepingcomputer.com/startups/
Disable any unneeded services
Go to start>run>services.msc
Use this guide
http://www.blackviper.com/
Use Disk Defragmenter
Go to start>all programs>accessories>system tools>disk defragmenter
You also may need to add more RAM
http://www.bleepingcomputer.com/tutorials/tutorial122.html
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